脓毒症时微循环障碍、细菌毒素、炎症因子、营养不良等都可导致肝损伤[1-2]。但临床研究发现,针对以上机制的治疗措施并不能有效缓解肝损伤。近年研究表明,氧化应激在脓毒症导致的肝损伤中起到了至关重要的作用。氧化应激产物包括活性氧和活性氮,前者主要由线粒体和中性粒细胞生成,后者主要由内皮细胞生成。(1)活性氧导致肝损伤的机制包括脂质过氧化,线粒体损伤和细胞凋亡。 Sepsis microcirculation, bacterial toxins, inflammatory factors, malnutrition, etc. can lead to liver damage [1-2]. However, clinical studies have found that the treatment for these mechanisms does not effectively relieve liver damage. Recent studies show that oxidative stress plays a crucial role in liver injury caused by sepsis. Oxidative stress products include reactive oxygen species and reactive nitrogen, the former mainly by the mitochondria and neutrophils, the latter mainly by the endothelial cells. (1) The mechanisms by which reactive oxygen species cause liver damage include lipid peroxidation, mitochondrial damage and apoptosis.