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目的:探究苄星青霉素和头孢三嗪治疗早期梅毒的临床疗效。方法:选取2014年1月至2015年12月到广州市番禺区钟村医院进行临床治疗的90例早期梅毒患者,根据随机法把患者分成A、B、C、3个组,每组30例,给予A组患者苄星青霉素进行治疗,给予B组患者头孢三嗪进行治疗,对于C组患者则采用头孢三嗪和苄星青霉素进行联合治疗。然后对比3组患者的临床疗效和梅毒血清检测结果转阴的平均时间。结果:临床治疗后1年随访中发现,C组患者TRUST的转阴率和平均转阴时间明显优于A、B两组;在临床疗效上,C组患者的总有效率高达93.33%,也明显优于A、B两组患者,3组患者数据比较,差异具有统计学意义(P<0.05)。结论:经临床研究发现,对于早期梅毒患者采用头孢三嗪与苄星青霉素联合治疗的方式相比于单药治疗临床效果更好。
Objective: To investigate the clinical efficacy of benzathine penicillin and ceftriaxone in the treatment of early syphilis. Methods: From January 2014 to December 2015, 90 early syphilis patients who were treated clinically in Zhongcun Hospital, Panyu District, Guangzhou were randomly divided into three groups: A, B and C, 30 patients in each group , Giving group A patients with benzathine penicillin for treatment, giving group B patients ceftriaxone for treatment, for group C patients using cefepime and benzathine penicillin for combination therapy. Then compared the clinical efficacy of three groups of patients and syphilis serum test results negative average time. Results: One year follow-up after treatment showed that the negative conversion rate and average negative conversion time of TRUST in group C were significantly better than those in groups A and B. The total effective rate in group C was as high as 93.33% Significantly better than A, B two groups of patients, three groups of patients data, the difference was statistically significant (P <0.05). Conclusion: The clinical study found that the early syphilis patients treated with ceftriaxime and benzathine penicillin compared to the clinical efficacy of monotherapy better.