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目的探讨依达拉奉在烧伤休克导致急性肺损伤大鼠的抗氧自由基作用。方法24只大鼠随机分为烧伤休克组(A组)、烧伤休克+依达拉奉给药组(B组)和对照组(C组),每组8只。休克6 h后检测血浆丙二醛(MDA)、超氧化物歧化酶(SOD)、谷光甘肽(GSH)及谷光甘肽过氧化物酶(GSH-px)含量,评定氧自由基水平。结果B组MDA[(3.35±0.28)nmol/L vs.(3.88±0.28)nmol/L]明显低于A组,而SOD[(76.12±11.25)U/ml v.s(72.32±9.36)U/ml]、GSH[(132.41±22.42)mg/L v.s(120.23±24.15)mg/L]、GSH-px[(754.54±101.23)mg/L vs.(685.56±102.37)mg/L]水平明显高于A组(P<0.05)。结论依达拉奉对烧伤休克所致大鼠的急性肺损伤有保护作用。
Objective To investigate the effect of edaravone on the anti-oxygen free radical in acute lung injury induced by burn shock in rats. Methods Twenty - four rats were randomly divided into burn shock group (group A), burn shock + edaravone group (group B) and control group (group C), with 8 rats in each group. Plasma levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-px) were measured 6 h after shock to assess the level of oxygen free radicals. Results MDA [(3.35 ± 0.28) nmol / L vs. (3.88 ± 0.28) nmol / L] in group B was significantly lower than that in group A, but SOD [(76.12 ± 11.25) U / ml vs (72.32 ± 9.36) U / ], GSH [(132.41 ± 22.42) mg / L vs (120.23 ± 24.15) mg / L] and GSH-px [(754.54 ± 101.23) mg / L vs. (685.56 ± 102.37) mg / L] Group A (P <0.05). Conclusion Edaravone has a protective effect on acute lung injury induced by burn shock in rats.