Conjugated block copolymers have gained increasing interests in recent years. Development of a novel method for facile synthesis of conjugated block copolymers with desired structures and functions is greatly desired. In this mini review, we summarized the recent advances in one-pot synthesis of conjugated block copolymers containing π-conjugated polythiophene and helical polyisocyanide segments by using a nickel(Ⅱ) complex as single catalyst. The sequential living polymerization of the two monomers proceeded in a controlled manner, affording expected block copolymers in high yields with controlled molecular weights(Mns) and narrow molecular weight distributions(Mw/Mns). By using this method, a family of block copolymers with expected structure and tunable compositions can be facilely prepared. Introducing functional groups onto the pendant, these block copolymers can exhibit interesting self-assembly property, tunable light emission and multi-responsiveness. Conjugated block copolymers have increasing more interests in recent years. Development of a novel method for facile synthesis of conjugated block copolymers with desired structures and functions is greatly desired. In this mini review, we summarize recent developments in one-pot synthesis of conjugated blocks copolymers containing π-conjugated polythiophene and helical polyisocyanide segments by using a nickel (Ⅱ) complex as single catalyst. The sequential living polymerization of the two monomers proceeded in a controlled manner, affording expected block copolymers in high yields with controlled molecular weights (Mns) Introducing functional groups onto the pendant, these block copolymers can exhibit interesting self-assembly properties, and the narrow molecular weight distributions (Mw / Mns). By using this method, a family of block copolymers with expected structures and tunable compositions can be facilely prepared. tunable light emission and multi-responsiveness.