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为研究药物及其基质对鼻粘膜纤毛活动的影响,作者等研究了盐酸麻黄素、苯海拉明、醋酸氢化可的松的水溶液和水溶液加聚合物(羟丙甲基纤维素、聚乙烯醇、甲基纤维素)及上述药物的水溶性聚合物薄膜对纤毛上皮输运功能的影响。以青蛙食管上皮做生物学模型:将已破坏脊髓的青蛙仰卧固定,做纵切口剖开咽、食管和胃的一部分,展平食管固定并使之稍有张力,食管边缘放一有毫米刻度的纸条,试验在20～22℃的相同条件下进行,为避免干涸,用0.6%氯化钠溶液(冷血动物的等张液)经常注洗食管粘膜面,先用秒表记录软木粒在食管中份粘膜上移动1cm的时间,再在食管粘膜上放置药物,记录有药物和注洗后1、2、3分钟软木粒移动
In order to study the effects of drugs and their matrix on nasal mucociliary activity, the authors studied the effects of ephedrine hydrochloride, diphenhydramine, hydrocortisone acetate in water and aqueous solutions plus polymers (hydroxypropylmethylcellulose, polyvinyl alcohol , Methyl cellulose) and the drug water-soluble polymer film on the ciliary epithelial transport function. To frog esophageal biological model: The spinal cord has been frog supine fixed, vertical incision to cut open the pharynx, part of the esophagus and stomach, flatten the esophageal fixed and make it a little tension, esophageal edge put a millimeter scale Notes, the test at 20 ~ 22 ℃ under the same conditions, in order to avoid dry, with 0.6% sodium chloride solution (cold blooded animal isotonic solution) often wash the esophageal mucosa surface, the first stopwatch record cork grain in the esophagus Mucosal movement 1cm time, and then place the drug in the esophageal mucosa, record the drug and 1,2,3 minutes after injection cork moving