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目的:考察醋炙芫花对毒性和药效的影响。方法:急性毒性试验采用BLiss法计算芫花和醋芫花的半数致死量;采用利尿试验试验,观察芫花和醋芫花不同极性溶剂提取物和不同极性部位对小鼠利尿作用的影响。结果:醋炙后芫花毒性明显毒性降低,乙酸乙酯部位是芫花的毒性部位。与对照组相比,芫花、醋芫花醇提物、石油醚部位、乙酸乙酯部位可明显促进利尿作用。与生品比较,醋炙后各组利尿作用皆明显增强。结论:芫花醋炙后毒性显著降低,药效增强。芫花的乙酸乙酯部位既是其毒性部位,又是其药效学主要部位。
Objective: To investigate the effect of vinegar Sunburn Daphne genkwa on toxicity and pharmacodynamics. Methods: Acute toxicity test was used to calculate the half-lethal dose of Daphne genkwa and vine-daphne genkwa by BLiss method. The diuretic test was used to observe the diuretic effects of different polarity solvent extracts and different polar fractions of Daphne genkwa and Daphne genkwa . Results: After the vinegar Sunburn toxicity was significantly reduced, ethyl acetate area is the toxic parts of Daphne genkwa. Compared with the control group, Daphne genkwa, ethanol extract of vinegar, genkwa, petroleum ether and ethyl acetate could significantly promote diuresis. Compared with the raw product, the effect of diuretic in each group after the vinegar was obviously enhanced. Conclusion: The genkwa vinegar after Sunburn toxicity was significantly reduced, efficacy increased. The ethyl acetate fraction of Daphne genkwa is both a toxic site and a major site of its pharmacodynamics.