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作者用伊维菌素(IVM)0.05ug/ml、0.1 ug/ml和海群生(DEC)150ug/ml浓度在体外与兔血混合马来丝虫微丝蚴实验感染东乡伊蚊。12天后全部蚊虫进行个体解剖:伊维菌素组蚊体内未发现马来丝虫三期幼虫,而海群生组东乡伊蚊感染率为30.5％、对照组为36.0％。单剂量的伊维菌素以400ug/kg体重,对照组用无菌生理盐水,经皮下或腹腔液内注入微丝蚴阳性的长爪沙鼠。治疗组和对照组分別于治疗后间隔1、7、30和75天喂饲东乡伊蚊。实验组于治疗后1—15天蚊体内未发现幼虫,对照组东乡伊蚊自然感染率为13.6％—14.6％。在治疗后75天蚊体内检获L_3数目,仍低于对照组。本研究提示伊维菌素能降低马来丝虫在蚊媒中的传播作用。其作用方式将进一步探讨。
The authors inoculated with Aedes albopictus in vitro with a microflora of Malay filariasis mixed with rabbit blood at a concentration of 150 ug / ml of IVM 0.05 ug / ml and DEC 150 ug / ml. After 12 days, all the mosquitoes were dissected. The 3rd instar larvae of the malayian filariasis were not found in the ivermectin group, while the Aedes albopictus infection rate was 30.5% in the Haiqun group and 36.0% in the control group. A single dose of ivermectin at 400 ug / kg body weight, the control group with sterile saline, subcutaneous or intraperitoneal injection microfilaria positive Merlin. The treatment group and the control group were fed with Aedes albopictus at intervals of 1, 7, 30 and 75 days after treatment. In the experimental group, larvae were found within 1-15 days after treatment. The natural infection rate of Ae. Albopictus in the control group was 13.6% -14.6%. 75 days after treatment mosquito seized L_3 number is still lower than the control group. This study suggests that ivermectin can reduce the spread of malayian filaments in mosquito vectors. Its mode of action will be further explored.