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目的：探讨ADA、CEA和CA19-9在老年结核性及癌性胸腔积液鉴别诊断中的意义。方法随机选取我院2011-2012年118例肺结核或肺癌患者，比较治疗前后肺结核组和肺癌组患者ADA、CEA和CA19-9的数值。结果肺癌者胸腔积液中CEA、CA19-9的表达水平明显高于肺结核患者，ADA的表达水平明显低于肺结核患者，差异有统计学意义(P <0.05)， CEA、CA19-9及ADA联合诊断肺癌的阳性率高，CEA数值大于11ng/ml可初步判定为癌性胸腔积液，CEA、CA19-9及ADA联合诊断的灵敏度为98.31%，特异度为52.54%，准确度为97.46%。结论 ADA、CEA和CA19-9联合诊断对老年结核性及癌性胸腔积液的鉴别具有重要意义。“,”Objective To investigate the ADA, CEA and CA19-9 indicators of significance and diagnostic value for differentiating the benign and malignant pleural effusions. Method Collected 118 cases of patients with pleural effusions treated in our hospital, and divided into the benign group and the malignant group. Compared the results of ADA, CEA and CA19-9 between two groups. Results Malignancy tumor markers CEA and CA19-9 level of the malignant group were significantly higher than those in the benign group, while ADA level were significantly lower than that in the benign group, with statistically significant difference(P <0.05). And joint detection can significantly improve the diagnostic sensitivity(98.31%). Conclusion The joint detection of ADA, CEA and CA19-9 have important diagnostic significance and clinical value in differentiating the benign and malignant pleural effusions.