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目的:探讨依那普利(ACEI)联合心理护理对A型行为高血压患者早期肾脏损害的影响。方法:将60例高血压患者按照《A型行为类型评定量表》和血压测量结果分为A型行为高血压组(A组)、非A型行为高血压组(B组)各30例,停药2周以上,比较两组患者尿β2-微球蛋白、24 h尿蛋白定量、尿微量白蛋白排泄率及夜间尿量。而后将A组分为A1组15例(给予ACEI治疗)、A2组15例(ACEI联合心理护理治疗),待治疗3个月后复查并比较尿β2-微球蛋白、24 h尿蛋白定量、尿微量白蛋白排泄率及夜间尿量。结果:A组与B组患者尿β2-微球蛋白、24 h尿蛋白定量、尿微量白蛋白排泄率及夜间尿量比较差异有统计学意义(P<0.01,P<0.05);A1组与A2组患者治疗3个月后尿β2-微球蛋白、24 h尿蛋白定量、尿微量白蛋白排泄率及夜间尿量比较差异有统计学意义(P<0.01,P<0.05)。结论:ACEI联合心理护理可明显减轻A型行为高血压患者早期肾脏损害。
Objective: To investigate the effect of enalapril (ACEI) combined with psychological nursing on type A hypertensive patients with early renal damage. Methods: Sixty hypertensive patients were divided into type A behavioral hypertension group (group A) and non-type A behavioral hypertension group (group B) with 30 cases in each group according to “Type A Behavior Type Rating Scale” and blood pressure measurement results. After stopping for more than 2 weeks, the urinary β2-microglobulin, 24-h urinary protein, urinary microalbumin excretion and nocturnal urine volume were compared between the two groups. A group was divided into A1 group of 15 cases (given ACEI treatment), A2 group of 15 cases (ACEI combined psychological nursing treatment), to be treated 3 months after the review and comparison of urinary β2-microglobulin, 24 h urinary protein, Urinary albumin excretion rate and night urine volume. Results: The urinary albumin excretion rate and urinary albumin excretion rate in group A and group B were significantly lower than those in group B (P <0.01, P <0.05) The urinary β2-microglobulin, 24-hour urinary protein, urinary albumin excretion rate and night urine volume in A2 group were significantly different after 3 months treatment (P <0.01, P <0.05). Conclusion: ACEI combined with psychological care can significantly reduce early renal damage in type A hypertensive patients.