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目的观察舒胃汤对功能性消化不良(FD)大鼠血清干细胞因子(SCF)、一氧化氮(NO)的影响,探讨舒胃汤治疗FD的作用机制。方法将60只SD大鼠随机分为空白组、模型组、木香顺气丸组、莫沙必利组、舒胃汤低剂量组、舒胃汤高剂量组共6组,每组10只。除空白组外其余5组通过夹尾刺激方法制造功能性消化不良模型。模型组和空白组不给予药物处理,其余各组大鼠分别给予相应药物灌胃治疗14 d。采用ELASA法检测大鼠血清SCF、硝酸还原酶法检测大鼠血清NO含量变化。结果与空白组比较,模型组大鼠血清NO升高,SCF降低(均为P<0.05),差异有统计学意义;舒胃汤治疗后血清SCF升高(P<0.05),NO降低差异有统计学意义(P<0.05)。结论舒胃汤能够调节功能性消化不良大鼠血浆NO、SCF水平的变化,恢复胃肠道运动功能,从而起到对功能性消化不良的治疗作用。
Objective To observe the effects of Shuweitang on serum levels of stem cell factor (SCF) and nitric oxide (NO) in rats with functional dyspepsia (FD) and to explore the mechanism of Shuweitang in treating FD. Methods Sixty Sprague Dawley rats were randomly divided into 6 groups: model group, Muxiang Shunqi Pill group, mosapride group, Shuweitang low dose group and Shuweitang high dose group, with 10 rats in each group . Except the blank group, the other 5 groups were made functional dyspepsia models by tail-pinch stimulation. The model group and the blank group were not given drug treatment, the rest of the rats were given the corresponding drug gavage for 14 days. ELASA method was used to detect the changes of serum SCF and nitrate reductase in serum of rats. Results Compared with the blank group, serum NO increased and SCF decreased (all P <0.05) in the model group, the difference was statistically significant; the serum SCF increased (P <0.05) and NO decreased in the model group Statistical significance (P <0.05). Conclusion Shuweitang can regulate the plasma level of NO and SCF in functional dyspepsia rats and restore the function of gastrointestinal motility and thus play a therapeutic role in functional dyspepsia.