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[目的]探讨黄芪酒精提取液对大鼠骨骼肌收缩力的影响.[方法]灌胃给予200 mg/kg黄芪酒精提取液2周后,观察大鼠坐骨神经受刺激后腓肠肌及比目鱼肌的收缩力.[结果]黄芪酒精提取液缩短腓肠肌及比目鱼肌单收缩和完全性强直收缩潜伏期,增加单收缩最大收缩幅度,延长最大收缩时间及最大舒张时间;增加完全性强直收缩的最大收缩度,延长最大收缩时间.[结论]黄芪酒精提取液可增强大鼠骨骼肌的收缩力.
[Objective] To investigate the effect of astragalus alcohol extract on the contractility of rat skeletal muscle. [Methods] Two weeks after intragastric administration of 200 mg/kg astragalus alcohol extract, the contractile force of the gastrocnemius and soleus muscles after stimulation of the sciatic nerve in rats was observed. [RESULTS] Astragalus alcoholic extract shortened the latency of contraction and complete tonic contraction of gastrocnemius and soleus muscles, increased the maximum contraction amplitude of single contraction, prolonged the maximum contraction time and maximum diastolic time; increased the maximum contraction degree of complete tonic contraction and prolonged the maximum Contraction time. [Conclusion] Astragalus alcohol extract can increase the contractility of rat skeletal muscle.