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为了解山东省丁型肝炎病毒感染状况 ,并探讨丁型肝炎病毒 ( HDV)感染与乙型肝炎病毒 ( HBV)感染的关系 ,应用酶联免疫吸附试验 ( EL ISA)对山东省 2 681例乙型肝炎病毒感染者进行了血清丁型肝炎病毒抗体 (抗 - HDV)检测 ,共检出抗 - HDV阳性者 2 0 7例 ,阳性率 7.72 %。HBs Ag携带者组抗 - HDV阳性率 3.16% ,乙肝患者组抗 - HDV阳性率 13.15% ,两组之间的差异有非常显著性 ( P<0 .0 0 1)。在乙肝患者组中 ,慢性活动性肝炎患者和重症肝炎患者抗 - HDV阳性率高于急性肝炎患者和慢性迁延性肝炎患者 ,差异有非常显著性 ( P<0 .0 0 1) ,表明乙肝病史越长、病情越重 ,其抗 - HDV阳性率越高。提示乙肝患者联合或重叠感染 HDV与乙肝慢性化和病情加重的形成有关。
In order to understand the status of hepatitis D virus infection in Shandong Province and to explore the relationship between hepatitis D virus (HBV) infection and hepatitis D virus infection, ELISA was performed on 2 681 cases of B Hepatitis B virus was tested for serum hepatitis D virus (anti-HDV). A total of 270 anti-HDV positive cases were detected, the positive rate was 7.72%. The positive rate of anti - HDV in HBsAg carriers was 3.16%, and the positive rate of anti - HDV in patients with hepatitis B was 13.15%. There was a significant difference between the two groups (P <0.01). In hepatitis B patients, the positive rate of anti-HDV in patients with chronic active hepatitis and severe hepatitis was higher than that in patients with acute hepatitis and chronic persistent hepatitis, the difference was significant (P <0.01), indicating that the history of hepatitis B The longer the more serious the disease, the higher the anti-HDV positive rate. Tip hepatitis B patients with combined or overlapping HDV infection and hepatitis B chronic disease and the formation of aggravating.