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血小板活化因子(PAF)是一种脂质类介质,具有多种病生理活性。寻找PAF拮抗剂是目前国际药物研究的热门。本文介绍了从植物中分离出的有效的PAF拮抗剂,其构效关系及进一步合成改造的结果。
Platelet-activating factor (PAF) is a lipid-based mediator that has a variety of pathophysiological properties. Looking for PAF antagonists is the current international drug research. This article describes potent PAF antagonists isolated from plants, their structure-activity relationships and the results of further syntheses.