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自从放射性核素问世以来,人们即开始研制亲肿瘤放射性药物,试图通过放射性核素的阳性显影达到早期诊断、探测其转移程度和观察治疗效果。到目前为止,国内外已研制成功的亲肿瘤放射性药物有多种,但能满足临床需要者为数不多。除~(131)碘对诊断和治疗甲状腺转移癌有较大价值外,其他亲肿瘤放射性药物或因特异性不强,或因灵敏度不高,已逐渐被淘汰。70年代最受欢迎的~(67)镓-柠檬酸盐由于它在炎症病变中的蓄积,目前已成功地用于寻找脓肿原发病灶,诊断骨髓炎,且在这方面的应用已不亚于它对肿瘤的诊断价值。
Since the advent of radionuclides, people began to develop their own tumor radiopharmaceuticals, attempting to achieve early diagnosis through positive imaging of radionuclides, detecting the degree of metastasis and observing the therapeutic effect. So far, there are many kinds of pro-tumor radiopharmaceuticals that have been developed at home and abroad, but few are able to meet the clinical needs. In addition to ~ (131) iodine on the diagnosis and treatment of thyroid cancer have greater value, other pro-tumor radiopharmaceuticals because of the specificity is not strong, or because of the sensitivity is not high, has been gradually eliminated. The most popular gallium-citrate in the 1970s, due to its accumulation in inflammatory lesions, has been successfully used to find primary lesions of abscesses and to diagnose osteomyelitis in the 1970s, and its use has been as good as this It is the diagnostic value of the tumor.