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目的：探讨７５％高渗醋酯钠／６％右旋糖酐４０（ＨＡＤ）对高原创伤失血性休克的急救作用及其量效关系。方法：初进高原大鼠２６只，分为生理盐水对照组（７只），ＨＡＤ４ｍＬ／ｋｇ治疗组（６只），ＨＡＤ６ｍＬ／ｋｇ治疗组（６只）和ＨＡＤ８ｍＬ／ｋｇ治疗组（７只），动物戊巴比妥钠ｉｐ麻醉，右侧股骨粉碎性骨折加放血（６０ｋＰａ维持１ｈ）复制创伤失血性休克模型，观察一次性静脉输注上述几个剂量ＨＡＤ对创伤失血性休克大鼠血液动力学指标和动物存活时间的影响，以生理盐水作对照。结果：一次性静脉输注４ｍＬ／ｋｇ，６ｍＬ／ｋｇ，８ｍＬ／ｋｇＨＡＤ均能显著提升休克大鼠血压，改善包括左心室收缩压（ＬＶＳＰ），左心室内压最大变化速率（±ｄｐ／ｄｔｍａｘ），心肌最大收缩速度（Ｖｐｍ），心肌收缩向量环面积（Ｌｏ）在内的血液动力学指标，维持时间超过２ｈ，同时可明显延长休克动物的存活时间，其中以６ｍＬ／ｋｇ，８ｍＬ／ｋｇＨＡＤ效果最好，但这两剂量效果相当，无显著差异。结论：ＨＡＤ４～８ｍＬ／ｋｇ对高原创伤失血性休克大鼠有较好的早期急救作用，剂量以６ｍＬ／ｋｇ较为合适。
Objective: To investigate the first aid effect and its dose-response relationship of 7.5% hypertonic sodium acetate / 6% dextran 40 (HAD) on hemorrhagic shock in plateau. Methods: Twenty-six rats were randomly divided into saline control group (n = 7), HAD4mL / kg treatment group (n = 6), HAD6mL / kg treatment group (n = 6) and HAD8mL / kg treatment group , Animals were anesthetized with sodium pentobarbital ip, the right femoral comminuted fractures plus bleeding (6 0kPa maintain 1h) replicate traumatic hemorrhagic shock model to observe the one-time intravenous infusion of several doses of HAD traumatic hemorrhagic shock rats Hemodynamic indicators and animal survival time, with saline as a control. Results: The single intravenous infusion of 4 mL / kg, 6 mL / kg and 8 mL / kg of HAD significantly increased the blood pressure of shock rats and improved the parameters including the left ventricular systolic pressure (LVSP), the maximum rate of change of left ventricular pressure (± dp / dtmax) , Maximum myocardial systolic velocity (Vpm) and myocardial systolic vector annulus (Lo), the maintenance time was longer than 2h, and the survival time of shock animals was prolonged obviously. The effects of 6mL / kg, 8mL / kgHAD The best, but these two doses of considerable effect, no significant difference. Conclusion: HAD4 ~ 8mL / kg has a good early emergency response to platelet traumatic hemorrhagic shock in rats, and the dosage of 6mL / kg is more suitable.