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结核病仍为最具破坏性的细菌性疾病之一,发病率和死亡率都很高。结核分枝杆菌能侵入宿主免疫系统,在肺肉芽肿中持留,致使目前的抗结核药物无法杀灭菌体。近年来药物耐受以及伴有HIV感染的结核病发病率急剧增加都给结核的控制带来了很大的困难,迫切需要深入了解目前抗结核药物的作用机制及耐药机制、病菌繁殖的分子机制,以指导开发对持留菌和耐药菌更加有效的新型药物。文中介绍了近年来从现有药物中发现的具有抗结核活性的化合物,以及一些有开发潜能的抗结核药物靶点。
Tuberculosis is still one of the most devastating bacterial diseases with high morbidity and mortality. Mycobacterium tuberculosis can invade the host immune system, retained in the lung granuloma, resulting in the current anti-TB drugs can not kill bacteria. In recent years, the drug resistance and the sharp increase in the incidence of tuberculosis associated with HIV infection have brought great difficulties to the control of tuberculosis. There is an urgent need to understand in depth the mechanism of action and mechanism of drug resistance and the molecular mechanism of pathogen reproduction To guide the development of new drugs that are more effective against bacteriostasis and drug-resistant bacteria. In this paper, the compounds with anti-TB activity found in existing drugs in recent years and some potential anti-TB drug targets are introduced.