Background:Betel quid chewing has been a major risk factor for oral cancer (OC) in south China.This study aimed to analyze the scientific publications on the relationship between betel quid chewing and OC and construct a model to quantitatively and qualitatively evaluate pertinent publications from 1998 to 2017.Methods:The publications from 1998 to 2017 were retrieved from the Web of Science Core Collection database.Microsoft Excel,Thomson Data Analyzer,VOSviewer,and CiteSpace software were used to analyze the publication outcomes,joals,countries/regions,institutions,authors,research areas,and research frontiers.Results:A total of 788 publications on the relationship between betel quid chewing and OC published until October 25,2017,were identified.The top 4 related joals were Joal of Oral Pathology Medicine,Oral Oncology,Plos One,and Intational Joal of Cancer.The top five countries engaged in related research included China,India,the United States,the United Kingdom,and Malaysia.The corresponding disciplines,such as oncology,oral surgery,pathology,environmental and occupational health,and toxicology,were mainly concentrated in three disciplines.The subject terms squamous cell carcinoma,OC,betel quid,expression,oral submucous fibrosis,India,and p53 ranked first among research hotspots.The burst terms squamous cell carcinoma,OC,betel quid,and expression ranked first in research frontiers.Conclusions:Research in this area emphasized hotspots such as squamous cell carcinoma,OC,oral submucosal fibrosis,betel quid,and tobacco.The annual number of publications steadily decreased from 1998 to 2017,with a lack of a systematic study from interdisciplinary perspectives,inadequate pertinent joals,limited regions with the practice of betel quid chewing,and insufficient participation of researchers,which indicate that as the prevalence of OC increases,particularly in China,research in this area warrants further expansion.