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目的:探讨经软通道微创治疗高血压脑出血的疗效及对患者血清白细胞介素18(IL-18)、血管内皮生长因子(VEGF)、C反应蛋白(CRP)和肿瘤坏死因子α(TNF-α)的影响。方法:选择台州市中医院2017年4月至2019年4月收治的高血压脑出血患者82例，依据随机数字表法分为观察组41例与对照组41例。对照组采用经硬通道微创治疗，观察组采用经软通道微创治疗。比较两组治疗疗效，术前和术后7 d颅内血肿量变化，术前和术后7 d血清IL-18、VEGF、CRP和TNF-α水平变化，术前和术后3个月神经功能缺损程度(NIHSS)评分变化，及术后并发症。结果:观察组总有效率(92.68%)高于对照组(70.73%)(χn 2＝6.609，n P<0.05)；观察组术后7 d颅内血肿量(4.03±1.10)mL，低于对照组的(7.17±1.36)mL(n t＝11.495，n P<0.05)；观察组术后7d血清IL-18(123.74±10.27)ng/L、VEGF(113.28±12.10)ng/L、CRP(17.83±3.20)mg/L、TNF-α(0.65±0.12)ng/L，均低于对照组的(150.38±13.21)ng/L、(141.63±16.87)ng/L、(29.96±4.53)mg/L、(1.09±0.17)ng/L(n t＝11.638、9.101、13.831、5.569，均n P<0.05)；观察组术后3个月NIHSS评分(16.53±3.19)分，低于对照组的(23.43±4.65)分(n t＝7.824，n P<0.05)；观察组并发症发生率(12.20%)低于对照组(34.15%)(χn 2＝5.549，n P<0.05)。n 结论:软通道微创治疗高血压脑出血患者疗效良好，可降低血清IL-18、VEGF、CRP和TNF-α水平。“,”Objective:To investigate the effect of soft channel minimally invasive treatment on hypertensive intracerebral hemorrhage (HICH) and its influence on serum interleukin-18 (IL-18), vascular endothelial growth factor (VEGF), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α).Methods:From April 2017 to April 2019, 82 patients with HICH admitted to Taizhou Hospital of Traditional Chinese Medicine were randomly divided into observation group (41 cases) and control group (41 cases) according to random number table method.The control group was treated with hard channel minimally invasive treatment, while the observation group was treated with soft channel minimally invasive treatment.The therapeutic effect, intracranial hematoma volume, serum levels of IL-18, VEGF, CRP and TNF-α before and 7 days after operation, neurological deficit degree (NIHSS) scores before and 3 months after operation, and complications after operation were compared between the two groups.Results:The total effective rate of the observation group (92.68%) was higher than that of the control group (70.73%) (χn 2=6.609, n P<0.05). The amount of intracranial hematoma in the observation group [(4.03±1.10)mL] was lower than that in the control group [(7.17±1.36)mL] (n t=11.495, n P<0.05). At 7 d after operation, the serum levels of IL-18[(123.74±10.27)ng/L], VEGF[(113.28±12.10)ng/L], CRP[(17.83±3.20)mg/L] and TNF-α[(0.65±0.12)ng/L] in the observation group were lower than those in the control group [(150.38±13.21)ng/L, (141.63±16.87)ng/L, (29.96±4.53)mg/L and (1.09±0.17)ng/L] (n t=11.638, 9.101, 13.831, 5.569, all n P<0.05). The NIHSS score of the observation group[(16.53±3.19)points] was lower than that of the control group[(23.43±4.65)points] at 3 months after operation (n t=7.824, n P<0.05). The incidence of complications in the observation group (12.20%) was lower than that in the control group (34.15%) (χn 2=5.549, n P<0.05).n Conclusion:Soft channel minimally invasive treatment for HICH has good effect and can reduce the changes of serum levels of IL-18, VEGF, CRP and TNF-α.