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目的:探讨脱氢表雄酮(DHEA)对卵巢储备功能降低(DOR)患者行体外受精-胚胎移植(IVF-ET)治疗结局的影响。方法:对接受体外受精/卵胞浆内单精子注射(IVF/ICSI)助孕治疗的47例DOR患者DHEA辅助治疗前后周期进行自身对照研究,分析卵巢储备功能指标(基础激素水平、窦卵泡计数等)及周期治疗参数(卵泡数、获卵数、受精率、卵裂率、胚胎种植率、临床妊娠率、周期取消率、流产率等)的变化。结果:前后周期超促排卵方案无显著性差异,DHEA辅助治疗后基础窦卵泡计数、卵泡数、获卵数显著增加(P<0.05),卵裂率、胚胎种植率、临床妊娠率显著提高(P<0.05),周期取消率呈降低趋势(P>0.05),而受精率、流产率无差异(P>0.05)。结论:DHEA辅助治疗可以改善DOR患者卵巢储备功能,提高卵巢反应性,改善IVF治疗结局。
Objective: To investigate the effect of dehydroepiandrosterone (DHEA) on outcome of IVF-ET in patients with ovarian reserve reduction (DOR). Methods: A total of 47 DOR patients undergoing in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI) assisted treatment were enrolled in this study. Self-control study was performed to evaluate the ovarian reserve function index (basal hormone level, antral follicle count Etc.) and periodic treatment parameters (number of follicles, number of oocytes retrieved, fertilization rate, cleavage rate, embryo implantation rate, clinical pregnancy rate, cycle cancellation rate, abortion rate, etc.). Results: There was no significant difference in the pro-ovulation cycles between the two groups. The number of basal antral follicles, number of follicles and number of oocytes retrieved after DHEA adjuvant therapy were significantly increased (P <0.05), and cleavage rate, embryo implantation rate and clinical pregnancy rate were significantly increased (P <0.05). The rate of abolishment of cycle showed a decreasing trend (P> 0.05), but there was no difference in fertilization rate and abortion rate (P> 0.05). Conclusions: DHEA adjuvant therapy can improve ovarian reserve function, improve ovarian response and improve IVF outcome in patients with DOR.