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自海南粗榧树皮中分离出两种新的化合物即海南粗榧内酯和海南粗榧内酯醇,海南粗榧内酯是一种新抗癌有效成分。动物试验结果表明对L_(615)、S_(180)、Lewis肺癌P_(388)和L_(1210)均显活性。根据X-衍射分析、核磁共振谱、红外光谱、紫外光谱、旋光光谱和质谱等证明海南粗榧内酯是一种新的结构类型的抗癌化合物,其结构式为Ⅰ。海南粗榧内酯醇的结构与海南粗榧内酯的结构很相似,其结构的研究正在进行中。
Two new compounds, Hainan crude lactones and Hainan crude lactone alcohols, were isolated from the rough bark of Hainan Island. Hainan crude lactones are a new anticancer active ingredient. The results of animal experiments showed that L_ (615), S_ (180), Lewis lung cancer P_ (388) and L_ (1210) showed significant activity. According to X-ray diffraction analysis, nuclear magnetic resonance spectroscopy, infrared spectroscopy, ultraviolet spectroscopy, optical rotation spectroscopy and mass spectrometry, Hainan crude lactone is a new type of structural anticancer compound, its structural formula is I. The structure of crude lactone alcohol in Hainan is similar to that of Hainan crude lactone, and its structure research is in progress.