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灌注溶石于1891年由Walker首创,随着溶石剂的改进和灌注技术的提高,这种治疗方法逐渐获得推广,已成为残留残石的有效治疗措施之一,并日益引起广泛的重视。一、实验研究的新进展目前,溶石实验研究的重点主要集中在寻找高效溶石剂,改进给药途径和探索理想的实验模型等方面。 (一)溶石剂的研究:对于胆固醇性结石,在续单辛烷素研制成功之后,已发现辛酸的其他一些脂类对胆固醇结石的溶解效力更大。Thistle预言,这项发现将导致合成更理想的溶石剂,并可望在九十年代应用于临床。
Perfusion limestone was pioneered by Walker in 1891. With the improvement of dissolved-lime and the improvement of perfusion techniques, this method of treatment has been gradually popularized and has become one of the effective treatment measures for residual residual stone, and has drawn increasing attention. First, the new advances in experimental research At present, the focus of the experimental study of limestone mainly focused on the search for efficient limestone, to improve the route of administration and to explore the ideal experimental model and so on. (A) Study of Lysoliths: For cholesterol stones, it has been found that some other lipids of caprylic acid are more effective at dissolving cholesterol stones after the successful development of single octanoyls. Thistle predicts that this discovery will lead to the synthesis of more ideal limestone and is expected to be available clinically in the nineties.