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本实验观察了雷公藤与P物质(SP)对免疫功能的影响,并利用辣椒素(CAP)耗竭大鼠脊髓后角SP,进一步探讨了脊髓后角SP在雷公藤引起免疫抑制中的作用。实验结果提示雷公藤具有抑制细胞免疫的作用,其机制可能与脊髓后角SP含量增高有关,脊髓蛛网膜下腔注射(ith)辣椒素耗竭脊髓后角SP,既可提高白细胞介素-2(IL-2)的产生水平,也可减轻雷公藤所引起的免疫抑制效应,表明脊髓后角SP可能参与雷公藤的细胞免疫抑制作用。
In this experiment, the effects of Tripterygium wilfordii and Substance P (SP) on immune function were observed, and capsaicin (CAP) was used to deplete SP in the posterior horn of the rat spinal cord, and the role of SP in spinal dorsal horn in the immunosuppression caused by Tripterygium wilfordii was further investigated. The experimental results suggest that Tripterygium wilfordii can inhibit cellular immunity, and the mechanism may be related to the increase of SP content in the posterior horn of the spinal cord. Spinal subarachnoid injection (ith) capsaicin depletes the spinal cord posterior horn SP, which can increase interleukin-2 ( The production level of IL-2) can also reduce the immunosuppressive effects caused by Tripterygium wilfordii, suggesting that the spinal cord posterior horn SP may be involved in the cellular immunosuppressive effect of Tripterygium wilfordii.