半个多世纪前,英国伦敦郊区医院MaryWalker对重症肌无力病人进行了一项非随机、非盲、非对照,但相当成功的有关毒扁豆素的试验,发现抗胆碱酯酸制剂的有效性,为重症肌无力神经肌肉传递缺陷提供了证据,导致了类似药物用于此病的治疗。重症肌无力的合理治疗取决于对该病发病机理的理解。主要异常为:神经肌肉接合部位可利用的乙酰胆碱受 More than half a century ago, MaryWalker, a London suburban hospital in the UK, conducted a non-randomized, unblinded, uncontrolled, but quite successful trial of linderhanin in patients with myasthenia gravis and found that anticholinergics are effective , Provides evidence of neuromuscular transmission defects in myasthenia gravis resulting in the use of similar drugs for the treatment of this condition. The rational treatment of myasthenia gravis depends on the understanding of the pathogenesis of the disease. The main abnormalities are: Acetylcholine receptors available at neuromuscular junction