一位74岁病人患泌尿系统感染口服环丙氟哌酸500mg,每日2次。第3天出现发热、膝关节发炎、瘙痒性红斑丘疹。停用环丙氟哌酸后2日内,关节炎消退。但出疹发展至全身。患者在6个月内未服用过其它药物。体检还见有阴囊肿胀、腿凹陷性水肿、右膝轻度膨出、希伯登氏和布夏氏结节、膝不稳。还有跖痛伴足旋前畸型。血红蛋白、白细胞计数、分类、电解质、肌酸酐、抗核抗体、抗线粒体抗体,抗平滑肌抗体,肌酸激酶、醛缩酶、补体(C_3、C_4、 A 74-year-old patient with urinary tract infection received oral ciprofloxacin 500 mg twice daily. Day 3 fever, knee inflammation, pruritic erythema rash. Arthritis subsided within 2 days after discontinuation of ciprofloxacin. But the rash develops to the whole body. The patient has not taken other medications within 6 months. Physical examination also see swelling of the scrotum, leg pitting edema, mild swelling of the right knee, Hibden and Bouss nodules, knee instability. There are plantar pain with pronation pre-anomalies. Hemoglobin, leukocyte count, classification, electrolyte, creatinine, antinuclear antibody, anti-mitochondrial antibody, anti-smooth muscle antibody, creatine kinase, aldolase, complement (C_3, C_4,