心肾综合征(CRS)因心血管疾病与肾脏疾病共存,二者相互影响并产生恶性循环,导致临床用药矛盾,治疗困难,死亡风险高于单一心血管疾病或肾脏疾病,故引起广泛关注。关于其病理生理机制已在神经内分泌激活、血流动力学紊乱、全身炎症激活等方面有了较为系统的研究,然而,临床实践证实尽管控制了这些发病途径却仍未能阻止CRS的进展,这提示可能存在其他途径导致心、肾交互损害。随着肾移植技术的发展,人们发现透析患者在肾移植以后心血管事件的发病率及全因死亡率均 Heart and kidney syndrome (CRS) due to cardiovascular disease and kidney disease co-exist, the two affect each other and produce a vicious cycle, leading to contradiction between clinical medication, treatment difficulties, the risk of death higher than single cardiovascular disease or kidney disease, it attracted widespread attention. Although its pathophysiological mechanism has been systematically studied in the fields of neuroendocrine activation, hemodynamic disorders, and systemic inflammatory activation, clinical practice has proved that although controlling these pathways has not yet stopped the progress of CRS, this Suggesting that there may be other ways lead to heart and kidney interaction damage. With the development of renal transplantation, it was found that the incidence of cardiovascular events and all-cause mortality after dialysis in dialysis patients