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目的探讨液基薄层细胞技术(TCT)和常规巴氏涂片预测早期宫颈癌的价值。方法对2006年1月-2008年12月在我院就诊的患者同时进行TCT检测和常规巴氏涂片进行细胞学诊断,对细胞学结果异常的168例患者行阴道镜下宫颈活检或行LEEP术组织病检。结果常规巴氏涂片细胞学结果为:低度鳞状上皮内病变(LSIL)109例,高度鳞状上皮内病变(HSIL)58例,鳞状细胞癌(SCC)1例;TCT检测细胞学结果为:低度鳞状上皮内病变(LSIL)94例,高度鳞状上皮内病变(HSIL)69例,鳞状细胞癌(SCC)5例;病检结果为:炎症或鳞状上皮化生25例,CINⅠ73例,CINII～III65例,SCC5例。TCT检测和常规巴氏涂片细胞学结果与组织病理比较,CINII-III的诊断符合率分别为92.75%、74.13%;鳞状细胞癌的漏检率分别为0、80%。两者比较差异有统计学意义(P<0.01)。结论 TCT检测技术对早期宫颈癌的预测价值优于常规巴氏涂片。
Objective To investigate the value of liquid-based thin-layer cell (TCT) and conventional Pap smear in predicting early cervical cancer. Methods From January 2006 to December 2008, patients in our hospital were treated with TCT and conventional Pap smear for cytology. 168 patients with abnormal cytology underwent colposcopic cervical biopsy or LEEP Tissue disease examination. Results The results of conventional Pap smear cytology were as follows: 109 cases of low grade squamous intraepithelial lesion (LSIL), 58 cases of high grade squamous intraepithelial lesion (HSIL) and 1 case of squamous cell carcinoma (SCC) Results: There were 94 cases of low grade squamous intraepithelial lesion (LSIL), 69 cases of high grade squamous intraepithelial lesion (HSIL) and 5 cases of squamous cell carcinoma (SCC). The results of pathological examination were inflammation or squamous metaplasia 25 cases, CINⅠ73 cases, CINII ~ III65 cases, SCC5 cases. TCT test and conventional Pap smear cytology results compared with histopathology, CINII-III diagnostic coincidence rates were 92.75%, 74.13%; squamous cell carcinoma missed detection rate was 0,80%. The difference between the two was statistically significant (P <0.01). Conclusion The predictive value of TCT for early cervical cancer is better than that of conventional Pap smear.