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Two sulfated chitosan derivatives were prepared in this paper (CSA and CSB that is low and high replacement) and their medical effect was researched.Aim: to study the effect of chitosan derivatives on thrombus formation and cruor time in mice.Method: sixty mice were divided into six groups and each group was raised with chitosan derivatives(CSA、CSB)200 and 600 mg/kg, aspirin 10 mg/kg, and 0.5% sodium carboxymethyl cellulose 2 ml/mice respectively.The levels of thrombus formation and cruor time were calculated in mice.Conclusion: two kinds of sulfated chitosan of the different sulfur content had been successfully prepared, that is CSA: DD 21.23%; CSB: DD 42.21%.Their yields are all over 90%; CSA、CSB at doses of 200 mg/kg barely influence the rate of thrombus formation and cruor time, however, CSB at doses of 600 mg/kg significantly decreased the weight of thrombus and increased cruor time in mice: decreasing 14.21% thrombus weight and increasing 14.31% cruor time.
Two sulfated chitosan derivatives were prepared in this paper (CSA and CSB that is low and high replacement) and their medical effect was researched. Aim: to study the effect of chitosan derivatives on thrombus formation and cruor time in mice. Method: sixty mice were divided into six groups and each group was raised with chitosan derivatives (CSA, CSB) 200 and 600 mg / kg aspirin 10 mg / kg and 0.5% sodium carboxymethyl cellulose 2 ml / mice respectively. These levels of thrombus formation and cruor time were calculated in mice. Conlusion: two kinds of sulfated chitosan of the different sulfur content had been successfully prepared, that is CSA: DD 21.23%; CSB: DD 42.21%. The results are all over 90%; CSA, CSB at doses of 200 mg / kg significantly reduced the rate of thrombus formation and cruor time, however, CSB at doses of 600 mg / kg significantly decreased the weight of thrombus and increased cruor time in mice: decreasing 14.21% thrombus weight and increasing 14.31% cruor time.