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[目的]探讨无创正压通气(NPPV)治疗重度有机磷中毒(AOPP)併急性呼吸衰竭(ARF)中的临床应用。[方法]对32例AOPP并ARF的患者应用无创正压通气辅助呼吸,分析通气治疗前后呼吸频率(RR)、心率(HR)、平均动脉压(MAP)、血氧饱和度SaO2、血气分析结果,计算氧合指数(DO2/FiO2)等。[结果]27例患者RR、HR、PO2、PaCO2、MAP、PO2/FiO2治疗前后比较差异有统计学意义(P﹤0.01)。[结论]应用无创正压通气治疗AOPP并ARF可改善ARF的氧合及缓解患者呼吸困难等症状,可作为治疗AOPP并ARF治疗的一种手段。
[Objective] To explore the clinical application of noninvasive positive pressure ventilation (NPPV) in the treatment of severe acute organ failure of organophosphate poisoning (AOPP) and acute respiratory failure (ARF). [Methods] 32 patients with AOPP and ARF were assisted by noninvasive positive pressure ventilation. Respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP), blood oxygen saturation SaO2 and blood gas analysis were analyzed before and after ventilation , Calculate the oxygenation index (DO2 / FiO2) and so on. [Results] There were significant differences in RR, HR, PO2, PaCO2, MAP and PO2 / FiO2 before and after treatment in 27 patients (P <0.01). [Conclusion] The application of noninvasive positive pressure ventilation in the treatment of AOPP and ARF can improve the ARF oxygenation and alleviate the symptoms such as dyspnea in patients, which can be used as a treatment for AOPP and ARF.