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目的观察应用乙肝疫苗联合乙肝免疫球蛋白(HBIG)阻断乙肝母婴传播的效果,及不同的喂养方式和生产方式对乙肝母婴阻断的影响。方法在北京市望京地区选择2007年1月1日至2011年12月31日出生,母亲乙肝表面抗原(HBsAg)阳性的儿童,采用个案调查和血清学检测的方法,比较应用乙肝疫苗联合乙肝免疫球蛋白阻断乙肝母婴传播的效果,及不同喂养方式和生产方式对乙肝母婴阻断的影响。结果仅接种乙肝疫苗与乙肝疫苗联合接种乙肝球蛋白比较,差异有统计学意义(P<0.05);选择母乳喂养方式与人工喂养,对阻断乙肝母婴传播差异无统计学意义(P>0.05);选择自然分娩与剖宫产对阻断乙肝母婴传播,差异无统计学意义(P>0.05)。结论乙肝疫苗联合乙肝免疫球蛋白对阻断乙肝母婴传播的疗效是显著的,而与选择不同的喂养方式和生产方式对乙肝母婴阻断效果无影响。
Objective To observe the effect of hepatitis B vaccine combined with hepatitis B immunoglobulin (HBIG) in blocking the transmission of hepatitis B virus (HBV) and the effect of different feeding methods and modes of production on the block of hepatitis B virus (HBV). Methods Children from January 1, 2007 to December 31, 2011 in Beijing Wangjing were enrolled in this study. The mothers who were positive for hepatitis B surface antigen (HBsAg) were selected by case investigation and serological test. Hepatitis B vaccine combined with hepatitis B immunoglobulin The effect of blocking the mother-to-child transmission of hepatitis B and the effects of different feeding methods and modes of production on the block of hepatitis B virus (HBV). Results There was significant difference between hepatitis B vaccine and hepatitis B vaccine alone (P <0.05). The choice of breastfeeding method and artificial feeding had no statistical significance in blocking the transmission of hepatitis B virus (P> 0.05) ). Choosing spontaneous delivery and cesarean delivery had no significant difference in blocking mother-infant hepatitis B transmission (P> 0.05). Conclusion Hepatitis B vaccine combined with hepatitis B immunoglobulin is effective in blocking mother-to-child transmission of hepatitis B, but different feeding methods and modes of production have no effect on the blocking effect of hepatitis B virus.