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万古霉素万古霉素主要经肾脏排泄,用量的80%以上于24小时内在尿中发现。半衰期为6小时。肾功能损伤的患者,积累了很高的血清浓度,而药物不能被血液透析及腹膜透析所清除。动物研究发现万古霉素肾脏毒性不大,尽管死后的动物的肾脏中再发现有极高浓度
Vancomycin vancomycin is mainly excreted by the kidneys, more than 80% of the amount found in the urine within 24 hours. Half-life of 6 hours. Patients with impaired renal function have accumulated high serum concentrations and drugs can not be cleared by hemodialysis and peritoneal dialysis. Animal studies found that vancomycin was not toxic to the kidneys, although an extremely high concentration was found in the kidneys of post-mortem animals