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目的探讨伴神经内分泌分化的乳腺癌的病理组织学类型及特征。方法应用免疫组化方法及Ｇｒｉｍｅｌｉｕｓ嗜银染色，确认神经内分泌分化细胞，并进行组织学观察。结果伴神经内分泌分化的乳腺癌在光镜下可有５种不同的组织学形态，本组４例免疫组化结果ＮＳＥ和Ｓｙ全部阳性，ＣＨＧ－Ａ３例阳性。嗜银染色３例阳性。结论乳腺癌伴有神经内分泌分化是肿瘤异质性的表现，是乳腺癌的一种特殊类型，并具有一定的组织学特征
Objective To investigate the histological types and characteristics of breast cancer with neuroendocrine differentiation. Methods Immunohistochemical method and silver staining of Grimelius were used to confirm neuroendocrine differentiation cells and histological observation was performed. Results There were 5 different histological forms of breast cancer with neuroendocrine differentiation under light microscope. The immunohistochemical results of NSE and Sy were positive in 4 cases in this group, and CHG-A3 was positive in 3 cases. Silver staining was positive in 3 cases. Conclusion Breast cancer with neuroendocrine differentiation is a manifestation of tumor heterogeneity. It is a special type of breast cancer and has certain histological features.