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目的:观察黄芪注射液足三里穴位注射配合中药保留灌肠治疗慢性肾功能衰竭的临床疗效。方法:将64例患者随机分为治疗组和对照组各32例,对照组予爱西特口服治疗,治疗组采用黄芪注射液足三里穴位注射配合中药高位结肠保留灌肠治疗。观察临床症状及体征、尿素氮(BUN)、血肌酐(Cr)、血红蛋白(Hb)、血清白蛋白(Alb)、血钙(Ca~(2+))和血磷(P)的变化。结果:临床疗效总有效率治疗组为78.13%,对照组为53.13%,2组比较,差异有非常显著性意义(P<0.01),说明治疗组临床疗效优于对照组。治疗后治疗组与对照组的中医症状积分明显改善,与治疗前比较,差异均有非常显著性意义(P<0.01);2组间比较,差异有显著性意义(P<0.05)。治疗后对照组BUN、Cr较治疗前明显降低,差异有显著性意义(P<0.05)。治疗后治疗组各指标均有明显改善,与治疗前比较,差异均有显著性意义(P<0.05),其中BUN、Cr、胱抑素C、Alb、Hb与对照组治疗后比较,差异均有显著性意义(P<0.05)。结论:黄芪注射液足三里穴位注射配合中药保留灌肠可纠正钙磷代谢,升高血清白蛋白,改善症状及肾功能,从而延缓肾衰竭进程。
Objective: To observe the clinical effect of injecting Astragalus injection Zusanli points with traditional Chinese medicine retention enema in the treatment of chronic renal failure. Methods: Sixty-four patients were randomly divided into treatment group and control group, with 32 cases in each group. The control group was treated with Aixitiao. The treatment group was treated with injection of Astragalus injection at Zusanli point together with high colon enema of Chinese medicine. The changes of clinical symptoms and signs, BUN, Cr, Hb, Alb, Ca 2+ and P were observed. Results: The total effective rate of the treatment group was 78.13% in the control group and 53.13% in the control group. There was significant difference between the two groups (P <0.01), indicating that the clinical efficacy of the treatment group was better than that of the control group. After treatment, the TCM symptom scores of the treatment group and the control group were significantly improved, with significant difference compared with those before treatment (P <0.01). There was significant difference between the two groups (P <0.05). After treatment, the levels of BUN and Cr in the control group were significantly lower than those before treatment, the difference was significant (P <0.05). After treatment, the indexes in the treatment group were significantly improved (P <0.05), and the differences were statistically significant (P <0.05). The differences of the BUN, Cr, Cystatin C, Alb, Hb and the control group after treatment There was significant (P <0.05). Conclusion: Astragalus Injection Zusanli acupoints with traditional Chinese medicine retention enema can correct calcium and phosphorus metabolism, increase serum albumin, improve symptoms and renal function, thus slowing the process of renal failure.