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目的:检测新疆不同民族舌体鳞状细胞癌中HPV16、18表达率,并探讨HPV16、18感染的危险因素。方法:回顾性分析2004年6月~2013年6月本院明确诊断为舌鳞状细胞癌患者63例,利用PCR技术检测不同民族舌体鳞癌中HPV16、18总体及亚型感染率,并收集患者临床及详细病理资料,研究与HPV16、18感染的相关危险因素。结果:63例舌体鳞状细胞癌患者中,HPV16、18总体感染率为28.6%。HPV16感染率为23.8%;HPV18感染率为7.9%;HPV16及HPV18交叉感染2例,维吾尔族及汉族各1例。其中维吾尔族患者HPV16、18总体感染率为36.8%。哈萨克族患者HPV16、18总体感染率为10%。汉族HPV16、18总体感染率为29.4%。单因素分析显示:舌体鳞状细胞癌患者HPV感染与年龄、性别、民族、部位无统计学差异,而与吸烟和饮酒有统计学差异(P<0.05)。Logistic多因素回归分析显示:饮酒与HPV16、18感染相关(P<0.05)。结论:新疆不同民族HPV16、18总体感染率低于其他地区,不同民族HPV16、18感染率无统计学差异。吸烟、饮酒是舌体鳞状细胞癌HPV16、18感染的相关影响因素,饮酒是独立保护性因素。
Objective: To detect the expression rates of HPV16,18 in different ethnic tongue squamous cell carcinomas in Xinjiang and to explore the risk factors of HPV16,18 infection. Methods: Sixty-three patients diagnosed as tongue squamous cell carcinoma in our hospital from June 2004 to June 2013 were retrospectively analyzed. The overall and subtype infection rates of HPV16 and HPV18 in different ethnic tongue squamous cell carcinomas were detected by PCR. Collect clinical and detailed pathological data to study the risk factors associated with HPV16,18 infection. Results: In 63 cases of tongue squamous cell carcinoma, the overall infection rate of HPV16,18 was 28.6%. HPV16 infection rate was 23.8%; HPV18 infection rate was 7.9%; HPV16 and HPV18 cross-infection in 2 cases, 1 case of Uygur and Han. Among them, the overall infection rate of HPV16,18 in Uighur patients was 36.8%. The prevalence of HPV16,18 infection in Kazak people is 10%. Han HPV16,18 overall infection rate was 29.4%. Univariate analysis showed that HPV infection in tongue squamous cell carcinoma was not statistically different from age, gender, ethnicity and location, but statistically significant (P <0.05) with smoking and alcohol consumption. Logistic multivariate regression analysis showed that alcohol consumption was associated with HPV16,18 infection (P <0.05). Conclusion: The overall infection rates of HPV16 and HPV18 in different ethnic groups in Xinjiang are lower than those in other regions. The infection rates of HPV16 and HPV18 in different ethnic groups are not statistically different. Smoking and drinking are the related influencing factors of tongue squamous cell carcinoma HPV16,18 infection, alcohol drinking is an independent protective factor.