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在3所乙型肝炎发病率高的儿童机构中,随机选择(1)44名儿童于入所后1～2周内开始注射乙型肝炎免疫血清球蛋白(从血友病患者的血浆提取,抗乙型肝炎抗体最后的对流电泳滴度为1∶32,被动血凝滴度为1∶264,144,含抗a、d、y三种亚型抗体);(2)37名儿童于入所后1～2周内开始注射标准免疫球蛋白(对流电泳检查抗体阴性,而被动血凝滴度为1∶16)。两者剂量皆为0.01毫升/0.5公斤,每4个月注射1次。然后每月抽血检乙型肝炎抗原(HBAg)、抗HBAg抗体和谷草转氨酶(GOT)。这些儿童在入所前无肝炎史,6个月内未注射过免疫球蛋白,入所时HBAg阴性,抗HBAg抗体的被动血凝滴度在1∶16以下,GOT正常,年龄、性别等情况皆相仿,另选其中一所机构中同样条件的儿童52名为对照。
Among three children with a high prevalence of hepatitis B, 44 children were randomized to receive hepatitis B immune globulin (from plasma from patients with hemophilia, 1 to 2 weeks after admission Hepatitis B antibody by the last convection electrophoresis titers 1:32, passive hemagglutination titer 1: 264.44, containing anti-a, d, y three subtype antibodies); (2) 37 children after admission 1 ~ Standard immunoglobulin was started within 2 weeks (antibody negative by convection gel electrophoresis, with a passive hemagglutination titer of 1:16). Both doses are 0.01 ml /0.5 kg, injected once every 4 months. Hepatitis B antigens (HBAg), anti-HBAg antibodies and aspartate aminotransferase (GOT) were then taken monthly. These children had no history of hepatitis before admission, had not injected immunoglobulin within 6 months, had HBAg negative on admission, had a passive hemagglutination titer of 1:16 against HBAg antibodies, normal GOT, similar age, and gender , 52 of the children in the same institution in one of the two institutions were selected as controls.