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目的：探讨大剂量维生素Ｃ治疗颅脑病患者手术前后超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）的变化。方法：随机将４３例要进行颅脑手术的患者分成常规治疗组（对照组）及大剂量维生素Ｃ治疗组（治疗组），检测２组术前及术后１、３、７ｄ患者血浆中的ＳＯＤ、ＭＤＡ含量。结果：对照组ＭＤＡ含量术后１、３、７ｄ较术前均明显升高（Ｐ＜００１），而治疗组与对照组相比则显著降低（Ｐ＜００１）；ＳＯＤ活性对照组术后１、３、７ｄ逐渐降低，而治疗组则逐渐升高，但手术后与手术前相比，差异不显著（Ｐ＞００５），在术后ｄ７，２组相比，差异显著（Ｐ＜００５）。结论：颅脑术后患者体内脂质过氧化增强，大剂量维生素Ｃ治疗可增强机体清除超氧阴离子（Ｏ·２）能力，对保护脑细胞膜具有一定作用。ＳＯＤ、ＭＤＡ的水平可用于评价颅脑手术疗效。
Objective: To investigate the changes of superoxide dismutase (SOD) and malondialdehyde (MDA) in patients with craniocerebral disease treated with high-dose vitamin C. Methods: Forty-three patients undergoing craniocerebral operation were randomly divided into routine treatment group (control group) and high-dose vitamin C treatment group (treatment group), and plasma levels of SOD, MDA content. Results: The content of MDA in the control group was significantly higher than that before operation (P <001), while the content of MDA in the control group was significantly lower than that in the control group (P <001) Group decreased gradually at 1, 3 and 7 days after operation, but gradually increased in treatment group, but there was no significant difference between before and after operation (P> 005) Significant (P <005). Conclusion: In patients with craniocerebral injury, lipid peroxidation is enhanced. High-dose vitamin C treatment can enhance the ability of the body to scavenge superoxide anion (O 2) and play a role in protecting brain cell membrane. SOD, MDA levels can be used to evaluate the efficacy of cranial surgery.