含氟β-氨基酸和含氟β-内酰胺广泛应用于有机化学、药物发现和蛋白质生物学的研究中.因而含氟β-氨基酸和含氟β-内酰胺的合成工作深受广大研究者重视,目前已开发出该类化合物的合成和拆分方法.依据含氟β-氨基酸种类(α-氟取代β-氨基酸、α-三氟甲基取代β-氨基酸和β-三氟甲基-β-氨基酸),重点介绍近年来该领域的代表性工作. Fluoro-β-amino acids and fluorine-containing β-lactams are widely used in organic chemistry, drug discovery and protein biology research.So the synthesis of fluorine-containing β-amino acids and fluorine-containing β -lactams by the majority of researchers attention , Has been developed for the synthesis and resolution of these compounds.According to the fluorine-containing β-amino acids (α-fluoro substituted β-amino acids, α-trifluoromethyl substituted β-amino acids and β-trifluoromethyl-β - Amino acids), highlighting the representative work in this area in recent years.