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例1:男,24岁,患急性前髓细胞性白血病。化疗时出现高热、寒战、恶心、剧烈肌痛及皮疹。皮疹主要在躯干及四肢,为单一型的暗红色坚实的丘疹。皮肤活检显示真皮血管周围非特异性淋巴细胞、组织细胞浸润,PAS 染色未发现酵母菌及菌丝,但多次血培养及脑脊液内找到热带性念珠菌。肌肉活检显示肌纤维束内有炎症和坏死性灶,未找到酵母菌。采用两性霉素 B 和5氟胞嘧啶治疗后皮疹消失,体温恢复正常。例2;女,45岁,患药物性粒细胞缺乏,出现高热及皮疹。皮疹见于上肢、胸、部分下肢,为紫红色
Example 1: Male, 24 years old with acute promyelocytic leukemia. Chemotherapy when fever, chills, nausea, severe myalgia and rash. Rash mainly in the trunk and limbs, a single type of dark red solid papules. Skin biopsy showed non-specific dermal perivascular non-specific lymphocytes, histological infiltration, PAS staining found no yeast and mycelium, but many blood cultures and cerebrospinal fluid to find tropical Candida. Muscle biopsy showed inflammation and necrosis within the muscle fiber bundles, not found in yeast. After amphotericin B and 5 flucytosine treatment rash disappeared, body temperature returned to normal. Example 2; Female, 45 years old, suffering from drug-induced neutropenia, fever and rash. Rash seen in the upper limbs, chest, some lower extremities, purple