论文部分内容阅读
目的:研究胃癌患者血清胰岛素样生长因子-1(IGF-1)水平与胃癌组织中血管内皮生长因子(VEGF)表达的关系。方法:采用放射免疫测定法(IRMA)及免疫组化SP染色法检测66例胃癌及18例正常对照的血清IGF-1水平及组织VEGF的表达。结果:胃癌患者血清IGF-1含量较正常对照组有显著升高(P<0.05),两组间VEGF的表达有明显差异(P<0.05)。不同IGF-1水平VEGF阳性表达差异有统计学意义(P<0.05)。结论:胃癌患者血清IGF-1水平与癌组织VEGF表达密切相关,提示IGF-1、VEGF可能参与了胃癌的发生发展过程,可望作为胃癌诊治的重要检测指标之一。
Objective: To investigate the relationship between the serum level of insulin-like growth factor-1 (IGF-1) and the expression of vascular endothelial growth factor (VEGF) in gastric cancer. Methods: The levels of serum IGF-1 and the expression of VEGF in 66 cases of gastric cancer and 18 cases of normal controls were detected by radioimmunoassay (IRMA) and immunohistochemical SP staining. Results: Serum IGF-1 levels in gastric cancer patients were significantly higher than those in normal controls (P <0.05). The expression of VEGF was significantly different between the two groups (P <0.05). The expression of VEGF in different IGF-1 levels had statistical significance (P <0.05). Conclusion: Serum IGF-1 levels in gastric cancer patients are closely related to the expression of VEGF in cancer tissues, suggesting that IGF-1 and VEGF may be involved in the development and progression of gastric cancer, which is expected to be one of the important detection indicators for the diagnosis and treatment of gastric cancer.