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目的探讨eIF4E在食管鳞状上皮癌变过程中的表达及其意义。方法采用免疫组织化学方法,检测食管正常鳞状上皮(15例)、食管鳞状上皮内瘤变(85例)和食管鳞状细胞癌(60例)中eIF4E在蛋白水平的表达情况。结果eIF4E在正常食管鳞状上皮组织,食管鳞状上皮内瘤变组织和鳞状细胞癌组织中的阳性表达率分别为26.7%、44.7%和63.3%,eIF4E在食管鳞状细胞癌中表达明显高于食管正常鳞状上皮组织及食管鳞状上皮内瘤变组织(P<0.05);高级别食管鳞状上皮内瘤变组织中eIF4E的阳性表达率显著高于正常食管鳞状上皮组织、低级别食管鳞状上皮内瘤变组织(P<0.05);低分化鳞癌组织中eIF4E的阳性表达率明显高于高分化鳞癌组织(P<0.05)。eIF4E的表达与临床病理特征不相关(P>0.05)。结论在食管鳞状上皮癌变过程中,eIF4E的表达呈增高趋势。eIF4E在食管鳞癌中的表达随肿瘤分化程度降低而增高,提示eIF4E在食管鳞状上皮癌变和进展过程可能发挥一定的作用。
Objective To investigate the expression of eIF4E in esophageal squamous carcinogenesis and its significance. Methods The expression of eIF4E protein in normal esophageal squamous epithelium (15 cases), esophageal squamous intraepithelial neoplasia (85 cases) and esophageal squamous cell carcinoma (60 cases) were detected by immunohistochemistry. Results The positive rates of eIF4E in normal esophageal squamous epithelium, esophageal squamous intraepithelial neoplasia and squamous cell carcinoma were 26.7%, 44.7% and 63.3%, respectively. The expression of eIF4E was significantly higher in esophageal squamous cell carcinoma Which was higher than that in normal esophageal squamous epithelium and esophageal squamous intraepithelial neoplasia (P <0.05). The positive expression rate of eIF4E in esophageal squamous intraepithelial neoplasia was significantly higher than that in normal esophageal squamous epithelium Grade esophageal squamous intraepithelial neoplasia (P <0.05). The positive rate of eIF4E in poorly differentiated squamous cell carcinoma was significantly higher than that in well-differentiated squamous cell carcinoma (P <0.05). The expression of eIF4E was not correlated with clinicopathological features (P> 0.05). Conclusion In the process of esophageal squamous carcinogenesis, the expression of eIF4E shows an increasing trend. The expression of eIF4E in esophageal squamous cell carcinoma with the degree of tumor differentiation decreased, suggesting that eIF4E may play a role in carcinogenesis and progression of esophageal squamous cell carcinogenesis.