脑活素是一种由猪大脑中提取的多种氨基酸的混合物水溶液,为奥地利EBEWE药厂产品,主要用于治疗脑血管疾病、颅脑外伤、脑震荡或脑挫伤后遗症等脑部疾患,随着临床应用的日趋广泛,其不良反应也日渐增多,现综述如下。 1 严重过敏反应 1.1 过敏性休克。李氏等报道1例男性患者,静滴脑活素,初始剂量10ml qd,10d后改为20ml qd,用药第12天后,病人突发恶寒、发热、心悸,给予异丙嗪25mg,im,无缓解,随即右上腹剧烈疼痛、烦燥,全身皮肤潮红,血压7/4kPa,诊断为过敏性 Cerebrolysin is an aqueous solution of a mixture of amino acids extracted from the pig’s brain. It is the product of the EBEWE pharmaceutical company in Austria and is mainly used in the treatment of brain disorders such as cerebrovascular diseases, craniocerebral trauma, concussion or sequelae of cerebral contusion. The clinical application of an increasingly wide range of adverse reactions are also increasing, are summarized below. 1 severe allergic reaction 1.1 anaphylactic shock. Li et al reported a male patient, intravenous drip cerebrotin, the initial dose of 10ml qd, 10d after the change to 20ml qd, 12 days after treatment, the patient sudden aversion to cold, fever, palpitations, given promethazine 25mg, im, No relief, then severe pain in the right upper quadrant, irritability, systemic skin flushing, blood pressure 7 / 4kPa, diagnosed as allergic