早产目前仍然是导致围产儿发病和死亡的主要原因,虽然现在临床广泛使用宫缩抑制剂、抗生素等治疗早产,但早产率并没有明显下降。经大量临床研究发现孕酮对预防早产有一定的作用,且有大量样本随机试验证实可适用于有自发早产史的孕妇,但其最佳用药途径、最佳用量、最佳给药时间及安全性仍有待临床试验进一步证实。 Premature birth is still the leading cause of perinatal morbidity and mortality. Although preterm birth is widely used in clinical practice, such as tocolytic agents and antibiotics, there is no obvious drop in preterm birth rate. After a large number of clinical studies found that progesterone to prevent preterm birth have a certain role, and a large number of randomized trials confirmed that the sample can be applied to pregnant women with spontaneous preterm birth, but the best route of administration, the optimal dosage, the best time to administer and safety Sex remains to be confirmed by clinical trials.