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Background: It is obvious that hemodialysis is a stressful process,leading to numerous social and psychological problems,and may cause fatigue and helplessness.Objective: This study aimed to explain the experiences of hemodialysis clients regarding the effect of psychological problems on fatigue.Methods: This article was extracted from a qualitative study conducted on clients undergoing hemodialysis in Khorramabad.To this end,a total of 15 participants were purposefully selected using the snowball sampling method and the required data was collected using individual,face to face,detailed and semi-structured interviews.There were 12 client interviewees and one doctor,one nurse and one hemodialysis client’s spouse.Content analysis was used to analyze the data.Results: Continuous analysis of data and documents obtained from the interviews on the hemodialysis clients’ experiences and comments regarding the main causes of fatigue revealed two main categories: 1) Psychological effects with subcategories of psychological stress and exhaustion;2) Needs and constraints with subcategories of individual and social needs and constraints.Conclusion: According to the clients’ speech and expression analysis,psychological impacts and disease-induced needs and constraints were the most important cause of fatigue and its continuation among these clients.