论文部分内容阅读
化合物(2)(即Azthreonam)对革兰氏阴性菌有很强的抗菌活性,并对β-内酰胺酶有卓越的稳定性。要合成化合物(1)的4位取代衍生物,必须解决(3)的制备。
Compound (2) (Azthreonam) has strong antibacterial activity against Gram-negative bacteria and excellent stability to β-lactamase. To synthesize the 4-substituted derivative of compound (1), the preparation of (3) must be solved.