胰岛素引起的变态反应很常见,其中大部分表现为迟发性过敏型的局部反应.过去已提出的致敏原因有:胰岛素制剂中的“沾染物”如脱酰胺胰岛素、附加物如鱼精蛋白、防腐剂如对羟基苯酸(Parabens)或胰岛素分子(牛或猪)本身等.但特异性变应原并未得以证实.本文报告2例注射胰岛素后引起局部皮肤过敏反应的病人,经临床和实验室检查结果证明致敏的原因是胰岛素中的锌. Insulin-induced allergic reactions are common, most of them manifesting as delayed-onset, allergic localized reactions.The allergens that have been suggested in the past include “contaminants” such as deamidated insulin in insulin preparations, supplements such as fish Protamine, preservatives such as parabens or insulin (bovine or pig) itself, etc. However, the specific allergen has not been confirmed.This article reports two cases of local dermal allergic reactions caused by insulin injection, Clinical and laboratory tests show that the cause of the sensitization is zinc in insulin.