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目的：寻找更有效的硬化剂治疗食管静脉曲张破裂出血。方法：配制一种新型硬化剂，其成分为１．５％孟氏液７０ｍｌ、２０％利多卡因２０ｍｌ、红霉素０．５ｇ及注射用水１０ｍｌ，将这种硬化剂注射到兔耳的血管内，还应用于９例肝硬化食管静脉曲张破裂出血病人，并设对照组。结果：新型硬化剂局部止血比５％鱼肝油酸钠和消痔灵的效果好，临床止血效果与１％乙氧硬化醇相同，且对动物肝、肾无损害。结论：新型硬化剂具有安全、有效、副作用小而价廉的优点。
OBJECTIVE: To find a more effective sclerotherapy for esophageal variceal bleeding. Methods: A new type of hardener was prepared, which consisted of 70% 1.5% Monteggia solution, 20ml lidocaine 20ml, erythromycin 0.5g and water for injection 10ml. The hardener was injected into the blood vessels of rabbit ears , Also applied to 9 cases of cirrhosis esophageal variceal bleeding patients, and set the control group. Results: The new sclerostin local hemostasis is better than 5% sodium morrhuate and Xiaozhiling. The effect of clinical hemostasis is the same as that of 1% ethoxylated alcohol, and no harm to animal liver and kidney. Conclusion: The new hardener has the advantages of safety, effectiveness, small side effects and low cost.