Biodegradable polymer stents vs second generation drug eluting stents:A meta-analysis and systematic

来源 :World Journal of Cardiology | 被引量 : 0次 | 上传用户:andychinajj
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
AIM: To evaluate the premise, that biodegradable polymer drug eluting stents(BD-DES) could improve clinical outcomes compared to second generation permanent polymer drug eluting stents(PP-DES), we pooled the data from all the available randomized control trials(RCT) comparing the clinical performance of both these stents.METHODS: A systematic literature search of Pub Med, Cochrane, Google scholar databases, EMBASE, MEDLINE and SCOPUS was performed during time period of January 2001 to April 2015 for RCT and comparing safety and efficacy of BD-DES vs second generation PP-DES. The primary outcomes of interest were definite stent thrombosis, target lesion revascularization, myocardial infarction, cardiac deaths and total deaths during the study period. RESULTS: A total of 11 RCT’s with a total of 12644 patients were included in the meta-analysis, with 6598 patients in BD-DES vs 6046 patients in second generation PP-DES. The mean follow up period was 16 mo. Pooled analysis showed non-inferiority of BD-DES, comparing events of stent thrombosis(OR = 1.42, 95%CI: 0.79-2.52, P = 0.24), target lesion revascularization(OR = 0.99, 95%CI: 0.84-1.17, P = 0.92), myocardial infarction(OR = 1.06, 95%CI: 0.86-1.29, P = 0.92), cardiac deaths(OR = 1.07, 95%CI 0.82-1.41, P = 0.94) and total deaths(OR = 0.96, 95%CI: 0.80-1.17, P = 0.71).CONCLUSION: BD-DES, when compared to second generation PP-DES, showed no significant advantage and the outcomes were comparable between both the groups. AIM: To evaluate the premise, that biodegradable polymer drug eluting stents (BD-DES) could improve clinical outcomes compared to second generation permanent polymer drug eluting stents (PP-DES), we pooled the data from all the available randomized control trials (RCT ) comparing the clinical performance of both these stents. METHODS: A systematic literature search of Pub Med, Cochrane, Google Scholar databases, EMBASE, MEDLINE and SCOPUS was performed during time period January 2001 to April 2015 for RCT and comparing safety and efficacy of BD-DES vs second generation PP-DES. The primary outcomes of interest were invasive stent thrombosis, target lesion revascularization, myocardial infarction, cardiac deaths and total deaths during the study period. RESULTS: A total of 11 RCT’s with a total of 12644 patients were included in the meta-analysis, with 6598 patients in BD-DES vs 6046 patients in second generation PP-DES. The mean follow up period was 16 months. Pooled analysis showed non-infer iority of BD-DES, comparing events of stent thrombosis (OR = 1.42, 95% CI: 0.79-2.52, P = 0.24), target lesion revascularization (OR = 0.99, 95% CI: 0.84-1.17, P = 0.92) (OR = 1.07, 95% CI 0.82-1.41, P = 0.94) and total deaths (OR = 0.96, 95% CI: 0.86-1.29, P = 0.92) 0.80-1.17, P = 0.71) .CONCLUSION: BD-DES, when compared to second generation PP-DES, showed no significant advantage and the outcomes were comparable between both groups.
其他文献
2015 ESC大会公布了OPTILINK-HF试验结果,该研究评估了在心力衰竭(简称心衰)患者置人能够检测胸腔积液量是否超过阈值并自动通知临床医师的装置,能否较标准临床评估降低心衰
三星2010年全新推出的蓝光播放器BD-C6900配备3D播放功能,并支持各种3D蓝游标准格式,同时,BD-C6900还支持三星Internet@TV网络直通功能,通过内置Wi-Fi和以太网通信模块,实现
一、可供出售资产概述可供出售金融资产是指初始确认时即被指定为可供出售的非衍生金融资产,以及除了贷款和应收款项、持有至到期投资、以公允价值计量且其变动计入当期损益
会议时间:1997年1月上旬,具体时间待第二轮通知时确定。 会议地点:哈尔滨 会议内容;铝金属及其合金阳极氧化、电解着色、轻合金表面陶瓷化工艺(简称PECC)、氧化磨沙处理、
铝活塞生产工艺过程中的平顶工序,大多数活塞生产厂家是通过专用机床或液压多刀半自动车床来完成的。我厂在1991年改造了一台C620车床,用以半自动循环加工活塞平顶,取得了良好的
Epigenetic modifications include DNA methylation, his-tone modifications, and micro RNA. Gene alterations have been found to be associated with cardiovascular d
1897年(清光绪二十三年) 9月16日(农历八月二十日,丁酉年丑时),出生于江苏省江阴县仓廪桥河西前村一个贫农家庭中。江阴县现为江阴市,仓廪桥属山观乡。其时家中还有祖母潘氏
河北文艺素有立足农村、表现农民、反映农业的创作传统,在各个历史阶段创作出一批深得农民喜爱、广受文坛好评的农村题材优秀作品。其中的电视剧创作在全国电视剧坛占有重要
为评价检测伴随乳腺癌的糖蛋白CA2 7 2 9和CA15 3的检测对原发性乳腺癌 (PBC)患者的诊断价值 ,作者回顾性探讨了 2 75例PBC患者血清CA2 7 2 9和CA15 3的浓度 ,并对全自动免疫化学发光系统
多种族动脉粥样硬化(MESA)研究的最新结果表明,冠状动脉钙化(CAC)进展似乎可剂量依赖性增加心房颤动(AF)发生风险。该研究结果近期发表于Circ Cardiovasc Imaging。研究者美