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β肾上腺素能阻滞剂(β阻滞剂)是最广泛应用的药物之一。其适应证包括高血压、心绞痛、心肌梗塞、及心律失常。近来大量研究集中于β阻滞剂延缓或抑制动脉粥样硬化及其并发症(动脉粥样化血栓形成性脑梗塞、心肌梗塞、心绞痛)的潜在能力。随着这种潜在的抗致动脉粥样硬化作用的研究,也涉及对由某些β阻滞剂诱发血脂的有害改变的不利影响,以及血脂致动脉粥样硬化改变,可能在某种程度上抵销这些药物的抗高血压裨益的可能性。现将β阻滞剂对动脉粥样硬化明确的和潜在的作用之有关证据分为“间接的”与“直接的”两类。间接作用通过检查高血压、
Beta-adrenergic blockers (beta blockers) are among the most widely used drugs. Indications include hypertension, angina, myocardial infarction, and arrhythmia. A large number of recent studies have focused on the potential of beta blockers to delay or inhibit atherosclerosis and its complications (atherothrombotic cerebral infarction, myocardial infarction, angina). As this potential anti-atherosclerotic study also involves the detrimental effects on the deleterious changes induced by certain beta blockers, as well as the lipid-induced changes in atherosclerosis, it may be that to some extent The potential for offsetting the antihypertensive benefit of these drugs. The relevant evidence for the definitive and potential role of beta blockers in atherosclerosis is divided into “indirect” and “immediate” categories. Indirect effect by checking for high blood pressure,