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目的评价复方利多卡因乳膏外涂与负压水动按摩治疗早泄的临床效果及安全性。方法 65例早泄患者,根据患者自身情况(有无治疗时间)随机分为复方利多卡因乳膏组(30例)和负压按摩组(35例)。复方利多卡因乳膏组外用复方利多卡因乳膏外涂阴茎头;负压按摩组采用负压水动按摩治疗。观察两组患者治疗后射精潜伏时间(IELT)变化。结果治疗前,复方利多卡因乳膏组与负压按摩组IELT分别为(0.92±0.32)、(0.89±0.35)min,比较差异无统计学意义(P>0.05);治疗后,复方利多卡因乳膏组与负压按摩组IELT分别为(6.12±0.53)、(3.92±0.25)min,治疗后两组患者IELT均有所改善(P<0.01),且复方利多卡因乳膏组明显优于负压按摩组(P<0.01)。复方利多卡因乳膏组不良反应发生率高于负压按摩组,差异有统计学意义(P<0.05)。结论复方利多卡因乳膏外涂及真空负压水动按摩治疗早泄均能显著延长IELT,复方利多卡因乳膏外涂效果更显著,但复方利多卡因乳膏外涂不良反应更明显。
Objective To evaluate the clinical efficacy and safety of compound lidocaine cream and negative pressure hydrodynamic massage in the treatment of premature ejaculation. Methods Sixty - five patients with premature ejaculation were randomly divided into compound lidocaine cream group (n = 30) and negative pressure massage group (n = 35) according to their own condition (with or without treatment time). Compound lidocaine cream compound topical compound lidocaine cream coated penis head; negative pressure massage group using negative pressure hydrodynamic massage treatment. Ejaculation latency (IELT) changes after treatment were observed in both groups. Results Before treatment, the IELT of compound lidocaine cream group and negative pressure massage group were (0.92 ± 0.32) and (0.89 ± 0.35) min respectively, with no significant difference (P> 0.05). After treatment, The IELT in the cream group and negative pressure massage group were (6.12 ± 0.53) and (3.92 ± 0.25) min, respectively, and the IELT in both groups was improved after treatment (P <0.01) Better than the negative pressure massage group (P <0.01). The incidence of adverse reactions of compound lidocaine cream group was higher than that of negative pressure massage group, the difference was statistically significant (P <0.05). Conclusion Compound Lidocaine cream and vacuum negative hydrodynamic massage can significantly prolong the IELT, but the effect of compound lidocaine cream is more obvious. However, the side effects of compound lidocaine cream are more obvious.