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目的：探讨喉粘膜上皮异型增生p53、H－ras过度表达与预后的关系。方法：应用免疫组化ABC法对63例喉粘膜上皮异型增生（经随访其中40例恶变为癌）、56例喉鳞癌和7例喉正常组织进行检测。结果：p53蛋白阳忖率在喉粘膜卜皮异型增生恶变组为50．0％，未恶变组为17.4％，喉癌组为51.8％，正常组织无表达。恶变组与未恶变组间，未恶变组与喉癌组间的p53蛋白表达差异有统计学意义（分别为P＜0．05和p＜0.01）。H－ras蛋白阳性率在喉正常组织、异型增生恶变组、未恶变组、喉癌组依次为0％、52．5％、522％和73．2％。恶变组和未恶变组间H－ras表达差异无统计学意义。结论：p53蛋白的过度表达与喉粘膜上皮异型增生的预后有密切关系。H－ras的表达与喉粘膜上皮异型增生的预后无关。
Objective: To investigate the relationship between p53 and H-ras overexpression and prognosis in laryngeal mucosal dysplasia. Methods: Immunohistochemical ABC method was used to detect 63 cases of laryngeal mucosal epithelial dysplasia (40 cases were malignant to cancer after follow-up), 56 cases of laryngeal squamous cell carcinoma and 7 cases of laryngeal normal tissues. Results: The positive rate of p53 protein in laryngeal mucosa dysplasia group was 50.0%, in non-malignant group 17.4% and in laryngocarcinoma group 51.8%, there was no expression in normal tissues. There was a significant difference in p53 protein expression between malignant group and non-malignant group (P <0.05 and p <0.01, respectively). The positive rate of H-ras protein was 0%, 52.5%, 522% and 73.2% in laryngeal normal tissue, dysplasia group, non-malignant group and laryngeal cancer group. There was no significant difference in H-ras expression between malignant group and non-malignant group. Conclusion: The overexpression of p53 protein is closely related to the prognosis of laryngeal mucosal dysplasia. The expression of H-ras was not associated with the prognosis of laryngeal mucosal dysplasia.