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目的 探讨D二聚体在川崎病急性期的变化和对冠状动脉损伤(CAL )的诊断价值。方法 检测川崎病(KD)组(n=4 8)治疗前后及对照组(n=30 )患儿血浆D二聚体浓度,分析D二聚体浓度与冠状动脉损伤的关系。结果 KD组血浆D二聚体浓度明显高于健康对照组(P<0 .0 5 ) ;KD组治疗3周后D二聚体水平低于治疗前(P<0 .0 5 ) ;CAL组D二聚体水平治疗前、治疗后均高于无CAL组,(P<0 .0 5 )。结论 D二聚体浓度对KD患儿急性期CAL有诊断价值;阿司匹林治疗能有效改善KD患者的血液高凝状态,从而减少KD患儿心血管并发症的发生。
Objective To investigate the changes of D dimer in the acute phase of Kawasaki disease and the diagnostic value of coronary artery injury (CAL). Methods Plasma D dimer concentration was measured in children with KD (n = 48) before and after treatment and in control group (n = 30), and the relationship between D dimer concentration and coronary artery injury was analyzed. Results The plasma D dimer concentration in KD group was significantly higher than that in healthy control group (P <0.05). The D dimer level in KD group was lower than that before treatment (P <0.05) D dimer levels before and after treatment were higher than those without CAL (P <0.05). Conclusions D-dimer concentration has diagnostic value in the acute stage of CAL in children with KD. Aspirin treatment can effectively improve the blood hypercoagulability in KD patients and thus reduce the incidence of cardiovascular complications in children with KD.